Plant sterols induce intestinal tumor formation in gender-related manner in ApcMin mice
نویسندگان
چکیده
Background Plant sterols are plant derived dietary compounds that are structurally similar to cholesterol. Plant sterols reduce cholesterol absorption, and therefore plant sterol enriched functional foods are designed to lower blood cholesterol level. Reduction of cholesterol absorption increases the level of intraluminal cholesterol, and high intraluminal cholesterol concentration has been associated with enhanced cell proliferation, aberrant crypt formation and tumor formation [1,2]. The aim of this study was to investigate, how plant sterols affect intestinal tumorigenesis, sterol composition of the faeces and the intestinal mucosa, and cell signaling in tumor-prone ApcMin mice.
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